Enzymatischer Abbau von Cephalosporin C

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Biosynthesis of cephalosporin C.

The superiority of d-methionine over l-methionine for stimulation of cephalosporin C synthesis in a crude medium was confirmed. The optimal level of dl-methionine was 0.5%. Methionine stimulates growth slightly but this is not thought to be the cause of the marked stimulation of antibiotic synthesis. Of a large number of sulfur compounds tested, only dl-methionine-dl-sulfoxide and S-methyl-l-cy...

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Cephalosporin C, an antibiotic with structure (I) (Abraham & Newton, 1961; Hodgkin & Maslen, 1961), was first isolated from an impure preparation of the chemically related penicillin NJ [(D-4amino-4-carboxybutyl)penicillin] that had been obtained from the culture fluid of a Cephalosporium sp. (Newton & Abraham, 1956; Abraham & Newton, 1956). The amount of cephalosporin C produced by this organi...

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Process strategies for cephalosporin C fermentation

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The X - Ray Analysis of Cephalosporin C

Bulow, C. & Seidel, F. (1924). Liebigs Ann. 439, 48. Cavallini, D., Frontali, N. & Toschi, G. (1949). Nature, Lond., 163, 568. De Ropp, R. S., Van Meter, J. C., De Renzo, E. C., McKerns, K. W., Pidacks, C., Bell, P. H., Ullman, E. F., Safir, S. R., Fanshawe, W. J. & Davis, S. B. (1958). J. Amer. chem. Soc. 80, 1004. Ellington, E. V., Hassall, C. H. & Plimmer, J. R. (1958). Chem. & Ind. p. 329. ...

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ژورنال

عنوان ژورنال: Pathobiology

سال: 1975

ISSN: 1423-0291,1015-2008

DOI: 10.1159/000162750